This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]
Function:
Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair.
Subcellular Location:
Nucleus.
Tissue Specificity:
Detected in heart, breast, prostate, skeletal muscle, testis, uterus, bone marrow, colon, small intestine, stomach and thymus.
Similarity:
Belongs to the exonuclease superfamily. TREX family.
SWISS:
Q9BQ50
Gene ID:
11219
Database links:
Entrez Gene: 11219 Human
Entrez Gene: 492236 Dog
Entrez Gene: 24102 Mouse
Entrez Gene: 309275 Rat
Omim: 300370 Human
SwissProt: Q9BQ50 Human
SwissProt: Q9R1A9 Mouse
Unigene: 644635 Human
Unigene: 23312 Mouse
Unigene: 63379 Rat
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