This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Expression of this gene was detected in most tissues. Its function, however, has not yet been determined. [provided by RefSeq, Jul 2008]
Function:
The TRIM16 gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. TRIM16 contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. The proteins of this family have been reported to be involved in a variety of biological processes including cell growth and differentiation. The TRIM16 gene is expressed in most tissues, and is more highly expressed in the fetus than in the corresponding adult tissues. TRIM16 may play a role in the regulation of keratinocyte differentiation.
Subcellular Location:
Cytoplasm.
SWISS:
O95361
Gene ID:
10626
Database links:
Entrez Gene: 10626 Human
Entrez Gene: 94092 Mouse
Entrez Gene: 100173399 Orangutan
Omim: 609505 Human
SwissProt: O95361 Human
SwissProt: Q99PP9 Mouse
SwissProt: Q5R760 Orangutan
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