fibronectin type-III and C-terminal SPRY motif protein;
Gene Y protein;
GeneY;
TRI46_HUMAN;
TRIFIC;
Trim46;
Tripartite;
Tripartite motif containing protein 46;
Tripartite motif-containing protein 46;
Tripartite, fibronectin type III and C termina
Cat:
SL16740R
Species Reactivity：
(predicted: Human,Mouse,Rabbit,)
Immunogen：
KLH conjugated synthetic peptide derived from human TRIM46:401-500/759
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
TRIM46 is a 759 amino acid intracellular protein that contains a variety of domains that are characteristic to TRIM proteins, including a RING-type zinc finger and a B box-type zinc finger. All subclass members, including TRIM46, TRIM9, TRIM67 and TRIM36, have conserved domain arrangement and associate with microtubule cytoskeleton, which may suggest that subcellular compartmentalization is determined by the unique domain architecture. The gene encoding TRIM46 is located on human chromosome 1, which spans about 260 million base pairs and comprises nearly 8% of the human genome.
Similarity: Belongs to the TRIM/RBCC family.
Contains 1 B box-type zinc finger.
Contains 1 B30.2/SPRY domain.
Contains 1 COS domain.
Contains 1 fibronectin type-III domain.
Contains 2 RING-type zinc fingers.
Specific References (1) | SL16740R has been referenced in 1 publications.
[IF=8.469] Tantai, Jicheng. et al. TRIM46 activates AKT/HK2 signaling by modifying PHLPP2 ubiquitylation to promote glycolysis and chemoresistance of lung cancer cells. Cell Death Dis. 2022 Mar;13(3):1-11 IHC ; Human.
