Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum.
Function:
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum.
Subunit:
Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration.
Subcellular Location:
Endoplasmic reticulum lumen.
Similarity:
Contains 1 thioredoxin domain.
SWISS:
Q9BS26
Gene ID:
23071
Database links:
Entrez Gene: 23071 Human
Entrez Gene: 506157 Cow
Entrez Gene: 474781 Dog
Entrez Gene: 100414815 Marmoset (common)
Entrez Gene: 76299 Mouse
Entrez Gene: 100192437 Pig
Entrez Gene: 59666 Rat
Omim: 609170 Human
SwissProt: Q3T0L2 Cow
SwissProt: Q9BS26 Human
SwissProt: Q9D1Q6 Mouse
Unigene: 154023 Human
Unigene: 317701 Mouse
Unigene: 2459 Rat
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