KLF16 is a 252 amino acid protein that contains three C2H2-type zinc fingers and belongs to the KLF transcription factor family. Localized to the nucleus and expressed at high levels in brain , KLF16 functions as a transcription factor that binds specifically to GT and GC boxes, displacing the transcription factors Sp1 and Sp3 and effectively modulating dopaminergic transmission in the brain.
Function:
Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the Sp1 C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.
SWISS:
Q9BXK1
Gene ID:
83855
Database links:
Entrez Gene: 83855 Human
Entrez Gene: 118445 Mouse
Entrez Gene: 690820 Rat
Omim: 606139 Human
SwissProt: Q9BXK1 Human
SwissProt: P58334 Mouse
Unigene: 136280 Human
Unigene: 41513 Mouse
Unigene: 18431 Rat
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