KLRF1, an activating homodimeric SLCtype lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]
Function:
KLRF1 is involved in the natural killer mediated cytolysis of PHA-induced lymphoblasts.
Subunit:
Homodimer.
Subcellular Location:
Membrane; Single-pass type II membrane protein
Tissue Specificity:
Strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Not expressed in brain, heart, placenta, lung, kidney, skeletal muscle, and pancreas. Within peripheral blood leukocyte and immunocyte cell lines, expression was predominant in NK cells but was also detected in monocytes.
Similarity:
Contains 1 SLCtype lectin domain.
SWISS:
Q9NZS2
Gene ID:
51348
Database links:
Entrez Gene: 51348 Human
Omim: 605029 Human
SwissProt: Q9NZS2 Human
|
|
