SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009]
Function:
KMT5C/SUV4-20h2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. KMT5C/SUV4-20h2 mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions.
Subunit:
Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 (By similarity). {ECO:0000250}.
Subcellular Location:
Nuclear.
Similarity:
Belongs to the class SLVlike SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
SWISS:
Q86Y97
Gene ID:
84787
Database links:
Entrez Gene: 84787 Human
Entrez Gene: 232811 Mouse
SwissProt: Q86Y97 Human
SwissProt: Q6Q783 Mouse
Unigene: 590982 Human
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