The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long SLCterminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]
Function:
Phosphorylates PPP1C, phosphorylase b and CFTR.
Subcellular Location:
Membrane.
Tissue Specificity:
Mainly expressed in skeletal muscle, and weakly in brain and pancreas.
Post-translational modifications:
Autophosphorylated. Phosphorylated.
Similarity:
Belongs to the protein kinase superfamily.
Tyr protein kinase family.
Contains 1 protein kinase domain.
SWISS:
Q8IWU2
Gene ID:
22853
Database links:
Entrez Gene: 22853 Human
Omim: 62209 Human
SwissProt: Q8IWU2 Human
Unigene: 444179 Human
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