This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jun 2009]
Function:
KRT24 is a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, comprise the cytoskeleton of epithelial cells. KRT24 is highly expressed in keratinocytes, placenta, colon and spleen, and has been found to be up-regulated in the mucosa of patients suffering of colorectal cancer.
Subcellular Location:
Intermediate filament; keratin
Similarity:
Belongs to the intermediate filament family.
SWISS:
Q2M2I5
Gene ID:
192666
Database links:
Entrez Gene: 192666 Human
Entrez Gene: 75706 Mouse
Omim: 607742 Human
SwissProt: Q2M2I5 Human
SwissProt: A1L317 Mouse
Unigene: 87383 Human
|
|
