The protein encoded by this gene is a member of the keratin superfamily. This keratin protein is a type I keratin that is specific for the inner root sheath of the hair follicle. This gene exists in a cluster with other keratin genes on chromosome 17q21. [provided by RefSeq, Jul 2009]
Subunit:
Heterotetramer of two type I and two type II keratins.
Tissue Specificity:
Strongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In the hair follicle, expression is restricted to the mid- to upper inner root sheath cuticle, being present slightly above the apex of the dermal papilla (at protein level).
Similarity:
Belongs to the intermediate filament family.
SWISS:
Q7Z3Y9
Gene ID:
353288
Database links:
Entrez Gene: 353288 Human
SwissProt: Q7Z3Y9 Human
Unigene: 592133 Human
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