In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Subunit:
Interacts with hair keratins.
Tissue Specificity:
Is essentially restricted to only one vertical half of the hair forming compartment and in beard hairs is absent from the central medulla.
Similarity:
Belongs to the KRTAP type 8 family.
SWISS:
Q8IUC2
Gene ID:
337879
Database links:
Entrez Gene: 337879 Human
SwissProt: Q8IUC2 Human
Unigene: 407655 Human
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