Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for efficient substrate-specific N-glycosylation probably involving the STT3A-containing OST complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.
Subunit:
Component of the oligosaccharyltransferase (OST) complex.OST seems to exist in different forms which contain at least RPN1,RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with STT3A.
Subcellular Location:
Endoplasmic reticulum membrane
Tissue Specificity:
Expressed in skin, heart, placental, liver, skeletal muscle, kidney, pancreas, keratinocytes and dermal fibroblasts.
Similarity:
Belongs to the KRTCAP2 family.
SWISS:
Q8N6L1
Gene ID:
200185
Database links:
Entrez Gene: 200185 Human
Entrez Gene: 66059 Mouse
SwissProt: Q8N6L1 Human
SwissProt: Q5RL79 Mouse
Unigene: 516671 Human
Unigene: 177991 Mouse
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