Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. KSHV ORF8 is a virion envelope-associated protein. Akula et al (2003) report it acts as a Glycoprotein B mediated signaling during virus entry. This Glycoprotein possesses the Arg-Gly-Asp (RGD) motif and utilizes alpha3beta1 integrin as one of the receptors for its entry into the target cells.
Function:
Envelope glycoprotein that forms spikes at the surface of the virion envelope. Participates in viral entry through an RGD motif that binds ITGASLVITGB3. Membrane fusion is mediated by the
fusion machinery composed at least of gB and the heterodimer gH/gL.
Subunit:
Homotrimer; disulfide-linked (By similarity)
Subcellular Location:
Virion membrane
Similarity:
Belongs to the herpesviridae glycoprotein B family
SWISS:
F5HB81
Gene ID:
4961501
Database links:
Entrez Gene: 4961501 HHV8 ORF8
SwissProt: F5HB81 HHSLV8
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