This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Function:
Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation.
Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
Subcellular Location:
Nucleus. Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex.
Tissue Specificity:
Widely expressed. Expression is reduced in colorectal cancer cell line SW96 and promyelocytic leukemia cell line HL-60.
Similarity:
Contains 1 C2HSLCtype zinc finger.
Contains 3 MBT repeats.
Contains 1 SAM (sterile alpha motif) domain.
SWISS:
Q9Y468
Gene ID:
26013
Database links:
Entrez Gene: 26013 Human
Entrez Gene: 241764 Mouse
Omim: 601762 Human
SwissProt: Q9Y468 Human
SwissProt: A2A5N8 Mouse
Unigene: 709356 Human
Unigene: 187086 Mouse
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