Voltage gated potassium (Kv) channels represent the most complex class of voltage gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KCNH3 is a pore forming (alpha) subunit of voltage-gated potassium channel. It elicits an outward current with fast inactivation.
Subunit:
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.
Subcellular Location:
Membrane; Multipass membrane protein.
Tissue Specificity:
Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus.
Similarity:
Contains 1 cyclic nucleotide-binding domain.
Contains 1 PAC (PAS-associated SLCterminal) domain.
Contains 1 PAS (PER-ARNT-SIM) domain.
SWISS:
Q9ULD8
Gene ID:
23416
Database links:
Entrez Gene: 23416 Human
Entrez Gene: 16512 Mouse
Entrez Gene: 27150 Rat
Omim: 604527 Human
SwissProt: Q9ULD8 Human
SwissProt: Q9WVJ0 Mouse
SwissProt: O89047 Rat
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