Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Function:
Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.
Subunit:
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH6/ERG2 (By similarity).
Subcellular Location:
Membrane; Multi-pass membrane protein
Tissue Specificity:
Expressed in prolactin-secreting adenomas.
Similarity:
Belongs to the potassium channel family.
Contains 1 cyclic nucleotide-binding domain.
Contains 1 PAC (PAS-associated SLCterminal) domain.
Contains 1 PAS (PER-ARNT-SIM) domain.
SWISS:
Q9NS40
Gene ID:
90134
Database links:
Entrez Gene: 90134 Human
Entrez Gene: 170738 Mouse
Entrez Gene: 170739 Rat
Omim: 608169 Human
SwissProt: Q4ZHQ8 Guinea pig
SwissProt: Q9NS40 Human
SwissProt: Q9ER47 Mouse
SwissProt: O54852 Rat
Unigene: 657413 Human
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