This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Outward rectifying potassium channel.
Subunit:
Homodimer (Potential).
Subcellular Location:
Membrane.
Tissue Specificity:
Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra.
Post-translational modifications:
Phosphorylation at Ser-348 controls the reversible conversion from a leak channel to a voltage-dependent channel.
Similarity:
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
SWISS:
O95069
Gene ID:
3776
Database links:
Entrez Gene: 3776 Human
Entrez Gene: 16526 Mouse
Entrez Gene: 170899 Rat
Omim: 603219 Human
SwissProt: O95069 Human
SwissProt: P97438 Mouse
Unigene: 497745 Human
Unigene: 33304 Mouse
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