Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids. [provided by RefSeq, Jul 2008]
Function:
KCNK4 belongs to the two pore domain potassium channel family and is an outward rectifying potassium channel. This channel produces rapidly activating and non-inactivating outward rectifier K(+) currents. It is activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
Subunit:
Homodimer; disulfide-linked.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Similarity:
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
SWISS:
Q9NYG8
Gene ID:
50801
Database links:
Entrez Gene: 50801 Human
Entrez Gene: 16528 Mouse
Entrez Gene: 116489 Rat
Omim: 605720 Human
SwissProt: Q9NYG8 Human
SwissProt: O88454 Mouse
Unigene: 647233 Human
Unigene: 12894 Mouse
Unigene: 46453 Rat
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