This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]
Function:
pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations.
Subcellular Location:
Membrane.
Tissue Specificity:
Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts. Not expressed in proximal tubules or glomeruli.
Similarity:
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
SWISS:
O95279
Gene ID:
8645
Database links:
Entrez Gene: 8645 Human
Entrez Gene: 16529 Mouse
Omim: 603493 Human
SwissProt: O95279 Human
SwissProt: Q9JK62 Mouse
Unigene: 444448 Human
Unigene: 68998 Mouse
|
|
