This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]
Function:
Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.
Subcellular Location:
Membrane.
Tissue Specificity:
Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain.
Similarity:
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
SWISS:
Q9Y257
Gene ID:
9424
Database links:
Entrez Gene: 9424 Human
Omim: 603939 Human
SwissProt: Q9Y257 Human
Unigene: 48395 Human
|
|
