Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Subcellular Location:
Membrane.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.
SWISS:
Q6PJI0
Gene ID:
3781
Database links:
Entrez Gene: 3781 Human
Entrez Gene: 395579 Chicken
Entrez Gene: 404177 Cow
Entrez Gene: 474128 Dog
Entrez Gene: 140492 Mouse
Entrez Gene: 54262 Rat
Omim: 605879 Human
SwissProt: Q6PJI0 Human
SwissProt: Q9H2S1 Human
SwissProt: P58390 Mouse
SwissProt: Q3UF29 Mouse
SwissProt: Q540U9 Mouse
SwissProt: Q80X11 Mouse
SwissProt: Q8C7F3 Mouse
SwissProt: Q8CAD4 Mouse
SwissProt: Q8CCH4 Mouse
SwissProt: P70604 Rat
Unigene: 98280 Human
Unigene: 458654 Mouse
Unigene: 44421 Rat
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