KCTD10, a potassium channel tetramerisation domain-containing 10 gene is a novel member of the polymerase delta-interacting protein 1 (PDIP1) gene family. KCTD10 shares significant similarity in amino acid sequence to PDIP1 and can interact with the small subunit of DNA polymerase delta and PCNA as PDIP1 does. Like PDIP1, the expression of KCTD10 gene can be induced by TNF-alpha in NIH3T3 cells.
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).
Subunit:
Component of the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1. Interacts with DNA polymerase delta subunit 2/POLD2 (By similarity). Interacts with PCNA.
Subcellular Location:
Nuclear
Similarity:
Belongs to the BACURD family.
Contains 1 BTB (POZ) domain.
SWISS:
Q9H3F6
Gene ID:
83892
Database links:
Entrez Gene: 83892 Human
Entrez Gene: 330171 Mouse
Entrez Gene: 494521 Rat
Omim: 613421 Human
SwissProt: Q9H3F6 Human
SwissProt: Q922M3 Mouse
SwissProt: Q7TPL3 Rat
Unigene: 524731 Human
Unigene: 238285 Mouse
Unigene: 185282 Rat
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