Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.
Tissue Specificity:
Broadly expressed in normal tissues.
Similarity:
Belongs to the KCTD3 family.
Contains 1 BTB (POZ) domain.
Contains 5 WD repeats.
SWISS:
Q9Y597
Gene ID:
51133
Database links:
Entrez Gene: 51133 Human
Entrez Gene: 226823 Mouse
Entrez Gene: 305055 Rat
Omim: 613272 Human
SwissProt: Q9Y597 Human
SwissProt: Q8SFX3 Mouse
Unigene: 335139 Human
Unigene: 209176 Mouse
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