Rabbit Anti-KDEL Receptor antibody

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ER lumen protein retaining receptor 1; ERD 2; ERD2; ERD2.1; ERD21_HUMAN; ERD21; HDEL; KDEL (Lys Asp Glu Leu) endoplasmic reticulum protein retention receptor 1; KDEL (Lys-Asp-Glu-Leu) 72 kD endoplasmic reticulum protein retention receptor 1; KDEL

Cat:

SL16938R

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Horse,Sheep,Xenopus laevis)

Immunogen：

KLH conjugated synthetic peptide derived from human KDEL Receptor:151-212/212

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a SLCterminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.

Function:
Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the SLCterminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi.

Subunit:
Upon ligand binding the receptor oligomerizes and interacts with components of the transport machinery such as ARFGAP1 and ARF1.

Subcellular Location:
Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane.

Post-translational modifications:
Phosphorylation by PKA at Ser-209 is required for endoplasmic reticulum retention function.

Similarity:
Belongs to the ERD2 family.

SWISS:
P24390

Gene ID:
10945

Database links:

Entrez Gene: 10945 Human

Entrez Gene: 618184 Cow

Entrez Gene: 68137 Mouse

Entrez Gene: 361577 Rat

Omim: 131235 Human

SwissProt: P33946 Cow

SwissProt: P24390 Human

SwissProt: Q99JH8 Mouse

SwissProt: Q569A6 Rat

Unigene: 515515 Human

Unigene: 298433 Mouse

Unigene: 1819 Rat

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