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Rabbit Anti-KDELR2 antibody
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a SLCterminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Function:
Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L.
Subcellular Location:
Endoplasmic reticulum membrane.
Similarity:
Belongs to the ERD2 family.
SWISS:
P33947
Gene ID:
11014
Database links:
Entrez Gene: 11014 Human
Entrez Gene: 66913 Mouse
Entrez Gene: 304290 Rat
Omim: 609024 Human
SwissProt: P33947 Human
SwissProt: Q9CQM2 Mouse
SwissProt: Q5U305 Rat
Unigene: 654552 Human
Unigene: 705873 Human
Unigene: 18376 Mouse
Unigene: 4066 Rat
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