Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]
Tissue Specificity:
Expressed exclusively in skin.
Post-translational modifications:
Undergoes deimination of some arginine residues (citrullination).
Similarity:
Belongs to the intermediate filament family.
SWISS:
Q7Z794
Gene ID:
374454
Database links:
Entrez Gene: 374454 Human
Omim: 611158 Human
SwissProt: Q7Z794 Human
Unigene: 334989 Human
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