KHDRBS2 (KH domain containing, RNA binding, signal transduction associated 2), is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. It induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer and may function as an adapter protein for Src kinases during mitosis. KHDRBS2 binds both poly(A) and poly(U) homopolymers.
Function:
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity).
Subunit:
Self-associates to form homooligomers.
Subcellular Location:
Nuclear
Tissue Specificity:
Highly expressed in brain, lung, kidney and small intestine. Weakly expressed in placenta, liver, spleen,thymus, ovary and colon.
Similarity:
Belongs to the KHDRBS family.
Contains 1 KH domain.
SWISS:
Q5VWX1
Gene ID:
202559
Database links:
Entrez Gene: 202559 Human
Entrez Gene: 170771 Mouse
Entrez Gene: 170843 Rat
GenBank: NM_152688 Human
Omim: 610487 Human
SwissProt: Q5VWX1 Human
SwissProt: Q9WU01 Mouse
SwissProt: Q920F3 Rat
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