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Rabbit Anti-KIAA1429 antibody
Made up of nearly 146 million bases, chromosome 8 encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder. Trisomy 8, also known as Warkany syndrome 2, most often results in early miscarriage but is occasionally seen in a mosaic form in surviving patients who suffer to a varying degree from a number of symptoms including retarded mental and motor development, and certain facial and developmental defects. WRN is a DNA helicase encoded by chromosome 8 and shown defective in those with the early aging disorder Werner syndrome. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome. The KIAA1429 gene product has been provisionally designated KIAA1429 pending further characterization.
Function:
May be involved in mRNA splicing regulation.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the vir family.
SWISS:
Q69YN4
Gene ID:
25962
Database links:
Entrez Gene: 25962 Human
Entrez Gene: 66185 Mouse
SwissProt: Q69YN4 Human
SwissProt: A2AIV2 Mouse
Unigene: 202238 Human
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