Rabbit Anti-KIAA1543 antibody

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Calmodulin regulated spectrin associated protein family, member 3; Calmodulin-regulated spectrin-associated protein 3; CAMP3_HUMAN; KIAA1543; NEZHA; Protein Nezha.

Cat:

SL17014R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human KIAA1543:851-950/1249

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fcα receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3. The KIAA1543 gene product has been provisionally designated KIAA1543 pending further characterization.

Function:
Microtubule minus-end binding protein that acts as a regulator of microtubule dynamics. Specifically required for zonula adherens biogenesis and maintenance by anchoring microtubules at their minus-ends to zonula adherens, leading to recruit KIFC3 kinesin to junctional site.

Subcellular Location:
Cell junction > adherens junction. Cytoplasm. Cytoplasm > cytoskeleton. Scattered in the cytoplasm. Localizes along zonula adherens only at mature cell-cell contacts.

Similarity:
Belongs to the CAMSAP1 family.
Contains 1 CH (calponin-homology) domain.
Contains 1 CKK domain.

SWISS:
Q9P1Y5

Gene ID:
57662

Database links:

Entrez Gene: 57662 Human

Omim: 612685 Human

SwissProt: Q9P1Y5 Human

Unigene: 17686 Human

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