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Rabbit Anti-KIAA1683 antibody
KIAA1683 is a 1,36 amino acid protein that contains six IQ domains, exists as three alternatively spliced isoforms, and is encoded by a gene that maps to human chromosome 19p13.11. Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG families, and Fcα receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE:
Contains 6 IQ domains.
Similarity:
Contains 6 IQ domains.
SWISS:
Q9H0B3
Gene ID:
80726
Database links:
Entrez Gene: 80726 Human
SwissProt: Q9H0B3 Human
Unigene: 313471 Human
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