Rabbit Anti-KIF16B antibody

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Chromosome 20 open reading frame 23; Kinesin like motor protein C20orf23; SNX23; KI16B_HUMAN; Sorting nexin 23.

Cat:

SL17041R

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human KIF16B:1-100/1317

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

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Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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KIF16B belongs to the kinesin like protein family. It may be involved in several stages of intracellular trafficking and is a probable microtubule dependent motor protein.

Function:
Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.

Subunit:
Interacts with RAB14 (By similarity). Interacts with PTPN21.

Subcellular Location:
Cytoplasm, cytoskeleton {ECO:0000305}. Early endosome membrane. Note=It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14.

Tissue Specificity:
Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level).

Post-translational modifications:
Isoform 4 is ubiquitinated at Lys-685.

Similarity:
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Contains 1 FHA domain. {ECO:0000305}.
Contains 1 kinesin motor domain.
Contains 1 PX (phox homology) domain.

SWISS:
Q96L93

Gene ID:
55614

Database links:

Entrez Gene: 55614 Human

SwissProt: Q96L93 Human

Unigene: 101774 Human

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