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Rabbit Anti-phospho-KIF20A (Ser528) antibody
Enables protein kinase binding activity. Involved in microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Located in several cellular components, including cleavage furrow; intercellular bridge; and midbody. Implicated in restrictive cardiomyopathy. [provided by Alliance of Genome Resources, Apr 2022]
Function:
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.
Subcellular Location:
Golgi apparatus. Cytoplasm > cytoskeleton > spindle.
Post-translational modifications:
Phosphorylated by PLK1 at Ser-528 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle.
Similarity:
Belongs to the kinesin-like protein family.
Contains 1 kinesin-motor domain.
SWISS:
O95235
Gene ID:
10112
Database links:
Entrez Gene: 10112 Human
Entrez Gene: 19348 Mouse
SwissProt: O95235 Human
SwissProt: P97329 Mouse
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