The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The SLCterminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Function:
Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA.
Subcellular Location:
Nucleus. Cytoplasm; cytoskeleton.
Post-translational modifications:
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
Similarity:
Belongs to the kinesin-like protein family.
Contains 1 kinesin-motor domain.
SWISS:
Q2967
Gene ID:
3835
Database links:
Entrez Gene: 3835 Human
Entrez Gene: 110033 Mouse
Entrez Gene: 293502 Rat
Omim: 603213 Human
SwissProt: Q2967 Human
SwissProt: Q3V300 Mouse
SwissProt: Q5I0E8 Rat
Unigene: 612151 Human
Unigene: 286488 Mouse
Unigene: 8601 Rat
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