Kinesins, such as KIF24, are microtubule-dependent ATPases that function as molecular motors. They play important roles in intracellular vesicle transport and cell division (summary by Venturelli et al., 2010 [PubMed 20670673]).[supplied by OMIM, Feb 2011]
Function:
Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation.
Subunit:
Interacts with CCP110 and CEP97.
Subcellular Location:
Cytoplasm; cytoskeleton.
Similarity:
Belongs to the kinesin-like protein family.
Contains 1 kinesin-motor domain.
Contains 1 SAM (sterile alpha motif) domain.
SWISS:
Q5T7B8
Gene ID:
34748
Database links:
Entrez Gene: 34748 Human
Omim: 613747 Human
SwissProt: Q5T7B8 Human
Unigene: 710246 Human
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