The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]
Function:
Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro.
Subcellular Location:
Cytoplasm > cytoskeleton.
Similarity:
Belongs to the kinesin-like protein family. Kinesin II subfamily.
Contains 1 kinesin-motor domain.
SWISS:
O15066
Gene ID:
9371
Database links:
Entrez Gene: 9371 Human
Entrez Gene: 16569 Mouse
Omim: 603754 Human
SwissProt: O15066 Human
SwissProt: Q61771 Mouse
Unigene: 369670 Human
Unigene: 315560 Mouse
Unigene: 41581 Rat
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