Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.
Subcellular Location:
Membrane.
Similarity:
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
KCNJ12 subfamily.
SWISS:
Q14500
Gene ID:
3768
Database links:
Entrez Gene: 403760 Dog
Entrez Gene: 100131509 Human
Entrez Gene: 10058070 Human
Entrez Gene: 3768 Human
Entrez Gene: 16515 Mouse
Entrez Gene: 117052 Rat
Omim: 602323 Human
SwissProt: Q4TZY1 Cow
SwissProt: Q14500 Human
SwissProt: P52187 Mouse
SwissProt: P52188 Rat
Unigene: 200629 Human
Unigene: 4970 Mouse
Unigene: 10406 Rat
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