SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008]
Function:
Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.
Subcellular Location:
Membrane.
Tissue Specificity:
In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells.
Similarity:
Belongs to the SLC43A transporter (TC 2.A.1.44) family.
SWISS:
O75387
Gene ID:
8501
Database links:
Entrez Gene: 8501 Human
Omim: 603733 Human
SwissProt: O75387 Human
Unigene: 591952 Human
Unigene: 735724 Human
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