This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
Function:
Tripeptidyl peptidase II is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It may be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Tripeptidyl peptidase II is a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class.
Subcellular Location:
Cytoplasmic
Similarity:
Belongs to the peptidase S8 family.
SWISS:
P29144
Gene ID:
7174
Database links:
Entrez Gene: 7174 Human
Entrez Gene: 22019 Mouse
Entrez Gene: 81815 Rat
Omim: 190470 Human
SwissProt: P29144 Human
SwissProt: Q64514 Mouse
SwissProt: Q64560 Rat
Unigene: 432424 Human
Unigene: 28991 Rat
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