tRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37) in selected tRNAs using S-adenosyl methionine (Brule et al., 2004 [PubMed 15248782]).[supplied by OMIM, Mar 2008]
Function:
Specifically methylates guanosine-37 in various tRNAs. Not dependent on the nature of the nucleoside 5' of the target nucleoside.
Subunit:
Monomer.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the TRM5 / TYW2 family.
SWISS:
Q32P41
Gene ID:
57570
Database links:
Entrez Gene: 57570 Human
Entrez Gene: 76357 Mouse
Omim: 611023 Human
SwissProt: Q32P41 Human
SwissProt: Q9D0C4 Mouse
Unigene: 380159 Human
Unigene: 311344 Mouse
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