DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points. Interacts with TMF1; may regulate TRNP1 proteasomal degradation.
Subcellular Location:
Nucleus.
SWISS:
Q6NT89
Gene ID:
388610
Database links:
Entrez Gene: 388610 Human
Entrez Gene: 69539 Mouse
Entrez Gene: 688990 Rat
SwissProt: Q6NT89 Human
SwissProt: Q80ZI1 Mouse
Unigene: 355747 Human
Unigene: 151594 Mouse
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