Syntaxins, a family of proteins involved in the fusion of synaptic vesicles with the plasma membrane, display broad tissue distribution and contain SLCterminal hydrophobic domains that direct them to their respective intracellular compartments. Syntaxin 17, also known as STX17, is a 302 amino acid single-pass type IV membrane protein that contains one t-SNARE coiled-coil homology domain and belongs to the syntaxin family. Thought to localize to the endoplasmic reticulum, Syntaxin 17 plays a role in vesicle trafficking to lysosomes and may be involved in processes related to cell division. The gene encoding Syntaxin 17 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.
Function:
Implicated in vesicle trafficking to lysosomes. Could be involved in processes related to cell division.
Subcellular Location:
Membrane. Appears to be associated with a membrane compartment, perhaps a subset of the ER such as exit or entrance sites.
Similarity:
Belongs to the syntaxin family.
Contains 1 t-SNARE coiled-coil homology domain.
SWISS:
P56962
Gene ID:
55014
Database links:
Entrez Gene: 55014 Human
Omim: 604204 Human
SwissProt: P56962 Human
Unigene: 704031 Human
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