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Rabbit Anti-Tropomodulin 4 antibody
Originally isolated from human erythrocytes, the tropomodulin (TMOD) family of proteins cap the pointed end of actin filaments (1,2). A component of the membrane skeleton, TMOD binds to the amino terminus of tropomyosin, which coats the surface of actin, and thus blocks the elongation and depolymerization of actin filaments (3,4). Four TMOD isoforms, TMOD1 - TMOD4, have been characterized in humans (2). TMOD expression is isoform-specific; TMOD3 is expressed ubiquitously, whereas TMOD2 and TMOD4 are expressed in neuronal tissue and muscle, respectively (5). TMOD4, which has a similar organization to TMOD2, is intergenically spliced by the putative transformation suppressor gene product YL-1 (1). The human TMOD4 gene maps to the telomeric end of chromosome 1q12, and encodes a 351 amino acid protein (1,5). The expression and chromosomal location of the TMOD4 gene make it a candidate for limb girdle musclular dystrophy 1B (5).
Function:
Tropomodulin 4 prevents the elongation and depolymerization of the actin filaments at the pointed end, and intervenes in the formation of the short actin protofilament, which determines the structure of the membrane skeleton.
Subunit:
Binds to the N-terminus of tropomyosin and to actin.
Subcellular Location:
Cytoplasm, cytoskeleton.
Tissue Specificity:
Highly expressed in skeletal muscle.
Similarity:
Belongs to the tropomodulin family.
SWISS:
Q9NZQ9
Gene ID:
29765
Database links:
Entrez Gene: 505645 Cow
Entrez Gene: 29765 Human
Omim: 605834 Human
SwissProt: Q0VC48 Cow
SwissProt: Q9NZQ9 Human
Unigene: 709681 Human
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