Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]
Function:
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane.
Subcellular Location:
Lysosome membrane. Endosome membrane.
Tissue Specificity:
Highest expression found in the heart and kidney, and lowest expression found in the spleen.
Similarity:
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.
SWISS:
Q9ULQ1
Gene ID:
53373
Database links:
Entrez Gene: 53373 Human
Entrez Gene: 252972 Mouse
Entrez Gene: 246215 Rat
Entrez Gene: 567534 Zebrafish
Omim: 609666 Human
SwissProt: Q9ULQ1 Human
SwissProt: Q9EQJ0 Mouse
SwissProt: Q9WTN5 Rat
Unigene: 524763 Human
Unigene: 114054 Mouse
Unigene: 24484 Rat
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