This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Function:
Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.
Tissue Specificity:
Detected in heart, kidney, testis, small intestine and peripheral blood leukocytes, and at very low levels in a variety of tissues.
Similarity:
Belongs to the thiamine pyrophosphokinase family.
SWISS:
Q9H3S4
Gene ID:
27010
Database links:
Entrez Gene: 27010 Human
Entrez Gene: 5967 Mouse
Entrez Gene: 136668 Rat
Omim: 606370 Human
SwissProt: Q9H3S4 Human
SwissProt: Q9R0M5 Mouse
Unigene: 660232 Human
Unigene: 64979 Mouse
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