The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008]
Function:
Involved in the fertilization process. May be involved in the fusion of the sperm with the egg.
Subunit:
Monomer, homodimer and homooligomer. Interacts with IZUMO1R/JUNO (By similarity).
Subcellular Location:
Membrane.
Tissue Specificity:
Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction.
Post-translational modifications:
N-glycosylated. Glycosylation is not essential for fusion and for proper protein trafficking in sperm.
Phosphorylated.
Similarity:
Belongs to the Izumo family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
SWISS:
Q8IYV9
Gene ID:
284359
Database links:
Entrez Gene: 284359 Human
Entrez Gene: 73456 Mouse
Entrez Gene: 499152 Rat
Omim: 609278 Human
SwissProt: Q8IYV9 Human
SwissProt: Q9D9J7 Mouse
SwissProt: Q6AY06 Rat
Unigene: 400688 Human
Unigene: 380445 Mouse
Unigene: 125416 Rat
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