Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.
/organism="Japanese encephalitis virus"
/strain="JE/vaccine/China/Chengdu-Institute-of-Biological-Products-SA14-14-2"
Subcellular Location:
Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein.
Post-translational modifications:
Disulfide bond.
SWISS:
Q90105
Gene ID:
50848
Database links:
SwissProt:
Q90105 JEV
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