JNK/SAPK-inhibitory kinase (JIK) is a serine/threonine kinase that belongs to the STE20 kinase family. The kinase domain of JIK is similar to the GCK-like subfamily of STE20 kinases, while its non-catalytic domain is similar to a Caenorhabditis elegans putative serine/threonine kinase, SULU. JIK inhibits c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK), which is activated by many types of cellular stresses and extracellular signals. JNK/SAPK regulates cell survival, apoptosis and proliferation in mouse development. JIK is negatively regulated by epidermal growth factor (EGF) and tyrosine kinase receptors. In unstimulated human T cells, JIK is cytoplasmic, whereas in the continuously dividing human T cells of Jurkat lymphoma, JIK is nuclear.
Function:
Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK.
Subcellular Location:
Cytoplasm. Cell membrane. Also localized to the peripheral cell membrane.
Tissue Specificity:
Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.
Post-translational modifications:
Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the protein kinase superfamily.
STE Ser/Thr protein kinase family. STE20 subfamily.
Contains 1 protein kinase domain.
SWISS:
Q9H2K8
Gene ID:
51347
Database links:
Entrez Gene: 51347 Human
Entrez Gene: 330177 Mouse
Entrez Gene: 10017800 Orangutan
Entrez Gene: 304530 Rat
Entrez Gene: 446778 Xenopus laevis
SwissProt: Q9H2K8 Human
SwissProt: Q9HC79 Human
SwissProt: Q8BYC6 Mouse
SwissProt: Q5R4F3 Orangutan
SwissProt: Q53UA7 Rat
SwissProt: Q6DD27 Xenopus laevis
Unigene: 644420 Human
Unigene: 24343 Mouse
Unigene: 248296 Mouse
Unigene: 162145 Rat
Unigene: 27040 Xenopus laevis
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