JMJD1C is a nuclear protein that belongs to the JHDM2 family of histone demethylases. Expressed in a wide variety of tissues, JMJD1C binds iron as a cofactor and contains one JMJC domain, a TRI8H1 domain with a C2HC4-type zinc finger-like motif and a TRI8H2 domain with a TR∫ (thyroid hormone receptor ∫)-binding region. JMJD1C demethylates lysine-9 of Histone H3, thereby playing a central role in the histone code and participating in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1C plays an important role in the regulation of cell growth during development and in chromatin regulation. Due to alternative splicing events, two isoforms exist for JMJD1C. One of these isoforms functions as a coactivator for the AR (androgen receptor).
Function:
Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes.
Subunit:
Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.
Subcellular Location:
Nucleus.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the JHDM2 histone demethylase family.
Contains 1 JmjC domain.
SWISS:
Q15652
Gene ID:
221037
Database links:
Entrez Gene: 221037 Human
Entrez Gene: 108829 Mouse
Entrez Gene: 171120 Rat
NCBI: NP_004232.2 Human
Omim: 604503 Human
SwissProt: Q15652 Human
SwissProt: Q69ZK6 Mouse
SwissProt: Q6NV48 Mouse
Unigene: 413416 Human
Unigene: 499821 Human
Unigene: 23846 Mouse
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