E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3.
Subcellular Location:
Endoplasmic reticulum. Cytoplasm. In cytoplasm colocalizes with CDK5RAP3.
Tissue Specificity:
Ubiquitously expressed, with a high expression in liver (at protein level). Low expression in several invasive hepatocellular carcinomas, such HepG2, Hep3B, HLE and PLC.
Post-translational modifications:
Ubiquitinated, leading to its degradation by the proteasome. Interaction with CDK5RAP3 protects each other against ubiquitination and degradation via the proteasome.
Similarity:
Belongs to the UFL1 family.
SWISS:
O94874
Gene ID:
23376
Database links:
Entrez Gene: 23376 Human
Entrez Gene: 67490 Mouse
Entrez Gene: 313115 Rat
Omim: 613372 Human
SwissProt: O94874 Human
SwissProt: Q8CCJ3 Mouse
SwissProt: B2GV24 Rat
Unigene: 149367 Human
Unigene: 226295 Mouse
Unigene: 12784 Rat
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