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Rabbit Anti-ZNF348/Kaiso antibody
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 SLCterminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]
Function:
Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.
Subunit:
Self-associates. Interacts with CTNND2 (By similarity). Interacts with CTNND1, and this interaction inhibits binding to both methylated and non-methylated DNA. Interacts with NCOR1. Interacts with KPNA2/RCH1, which may mediate nuclear import of this protein.
Subcellular Location:
Nucleus. Cytoplasm. Also cytoplasmic in cells grown at high densities.
Tissue Specificity:
Expressed in vascular endothelium.
Similarity:
Contains 1 BTB (POZ) domain.
Contains 3 C2H2-type zinc fingers.
SWISS:
Q86T24
Gene ID:
10009
Database links:
Entrez Gene: 10009 Human
Entrez Gene: 51365 Mouse
Entrez Gene: 501506 Rat
Omim: 300329 Human
SwissProt: Q86T24 Human
SwissProt: Q8BN78 Mouse
Unigene: 14724 Human
Unigene: 391248 Mouse
Unigene: 169266 Rat
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